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211P29

Tertiapin

H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Met-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH₂ (Disulfide bonds between Cys³ and Cys¹⁴/Cys⁵ and Cys¹⁸)

纯度:>95%HPLC
储存条价:-20 ± 5 °C,避光,干燥。

另提供从粗品至98%纯度规格,具体请联系我们!
本产品仅用于科学研究,不得用于人体!


产品详情

Cat#:211P29
序列(三字母):H-Ala-Leu-Cys-Asn-Cys-Asn-Arg-Ile-Ile-Ile-Pro-His-Met-Cys-Trp-Lys-Lys-Cys-Gly-Lys-Lys-NH₂ (Disulfide bonds between Cys³ and Cys¹⁴/Cys⁵ and Cys¹⁸)
序列(单字母):ALCNCNRIIIPHMCWKKCGKK-NH₂
分子式:C₁₀₆H₁₇₆N₃₄O₂₃S₅
分子量:2455.11
CAS#:58694-52-3
合成方法:Synthetic
存储条件:-20 ± 5 °C
应用:Ion Channel Modulating Agents
描述:Tertiapin (TPN), a potent inhibitor of the inward-rectifier K⁺ channels, blocked a G-protein-gated channel (GIRK1/4) and the ROMK1 channel with nanomolar affinities, however a closely related channel, IRK1, was insensitive to tertiapin. Thus, tertiapin will be a powerful ligand for purifying functional channels as well as for screening pharmaceutical agents against these channels.


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