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183P12

(Lys⁸-psi(CH₂NH)Lys⁹)-Neurotensin (8-13)

H-Lys-psi(CH₂NH)Lys-Pro-Tyr-Ile-Leu-OH

纯度:>95%HPLC
储存条价:-20 ± 5 °C,避光,干燥。

另提供从粗品至98%纯度规格,具体请联系我们!
本产品仅用于科学研究,不得用于人体!


产品详情

Cat#:183P12
序列(三字母):H-Lys-psi(CH₂NH)Lys-Pro-Tyr-Ile-Leu-OH
序列(单字母):K-psi(CH₂NH)KPYIL
类似名:JMV 449, (Lys8-acetyl-Lys9)-Neurotensin (8-13)
分子式:C₃₈H₆₆N₈O₇
分子量:746.99
CAS#:139026-66-7
合成方法:Synthetic
存储条件:-20 ± 5 °C
应用:Cancer Research
描述:Replacement of the Lys⁸-Lys⁹ peptide bond by the CH₂NH bond produced an analog with quite interesting pharmacological properties. The degradation-resistant peptide analog Lys-psi(CH2NH)Lys-Pro-Tyr-Ile-Leu (JMV-449) was the most active in the binding and biological assays. JMV-449 exhibited higher binding and biological potencies than neurotensin. JMV449 was also about 10 times more potent than neurotensin (8-13) in the bioassay, whereas both peptides were equipotent in the binding assay.


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