Cat#: 107P115
序列（三字母）：Ac-Leu-Pro-Phe-Phe-Asp-NH₂
序列（单字母）：Ac-LPFFD-NH₂
类似名：iAβ5p, Beta-sheet Breaker Peptide βiA 5p
分子式：C₃₅H₄₆N₆O₈
分子量：678.79
CAS#：339990-02-2
合成方法：固相合成
存储条件：-20 ± 5 °C，避光，干燥
应用：Alzheimer´s Disease
描述：The pentapeptide Ac-LPFFD-NH₂ (iAβ5p) is an analog of product with small chemical modifications which enhance its stability against proteolytic degradation. iAβ5p acts as a β-sheet breaker peptide and crosses the blood-brain barrier at a higher rate than most proteins and peptides known to be selectively taken up by the brain so that it is assumed that the peptide is being specifically transported to the brain. A significant increase in neuronal survival and decrease in brain inflammation associated with the reduction of amyloid plaques in two different transgenic Alzheimer`s disease (AD) models is additionally reported for iAβ5p.