Cat#: 107P111
序列（三字母）：H-D-Phe-D-Phe-D-Val-D-Leu-D-Lys-β-Ala-D-Lys(D-Lys-D-Leu-D-Val-D-Phe-D-Phe-H)-OH
序列（单字母）：ffvlk-β-Ala-D-Lys(klvff)-OH
类似名：ent-[retro-Amyloid β-Protein (16-20)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)]), (ffvlk)₂(βA)k (tandem dimer)
分子式：C₇₉H₁₁₉N₁₅O₁₃
分子量：1486.91
CAS#：1426174-31-3
合成方法：固相合成
存储条件：-20 ± 5 °C，避光，干燥
应用：Alzheimer´s Disease
描述：This all-D peptide contains two retro-inverso peptide klvff motifs of KLVFF (H-3682) corresponding to amino acids 16 to 20 of amyloid β-protein. The tandem dimer retro-inverso peptide showed about a 100-fold higher binding affinity (Kd = 1.3 · 10⁻² µM) for amyloid β-protein (1-40) fibrils than KLVFF (Kd = 1.1 ± 0.3 µM). It was also found to be more effective in preventing ordered fibril formation than the parent peptide KLVFF as judged by its increased ability to inhibit thioflavin T binding to β-sheet structures.