Cat#: 107P63
序列（三字母）：H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Val-Met-Val-Gly-Gly-Val-Val-OH
序列（单字母）：DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGVMVGGVV
类似名：Amyloid β-Protein (1-40) L34V, Amyloid β-Protein (1-40) Piedmont Mutation
分子式：C₁₉₃H₂₉₃N₅₃O₅₈S
分子量：4315.84
CAS#：1678415-83-2
合成方法：固相合成
存储条件：-20 ± 5 °C，避光，干燥
应用：Alzheimer´s Disease
描述：Cerebral amyloid angiopathy (CAA) is a common finding in Alzheimer’s disease in which amyloid-Aβ vascular deposits are featured in >80% of the cases. Mutations in the positions 21-23 (e.g. Dutch mutation E22Q) are primarily associated with CAA, although they manifest with strikingly different clinical phenotypes: cerebral hemorrhage or dementia. The Piedmont L34V Aβ mutant, located outside this hot spot, shows a similar hemorrhagic phenotype, albeit less aggressive than the widely studied Dutch variant.