Cat#: 107P58
序列（三字母）：H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Lys-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
序列（单字母）：DAEFRHDSGYEVHHQKLVFFAKDVGSNKGAIIGLMVGGVV
类似名：Amyloid β-Protein (1-40) Italian Mutation, Amyloid β-Protein (1-40) E22K, [Lys22] β-Amyloid (1-40)
分子式：C₁₉₅H₃₀₀N₅₄O₅₆S
分子量：4328.92
CAS#：302905-01-7
合成方法：固相合成
存储条件：-20 ± 5 °C，避光，干燥
应用：Alzheimer´s Disease
描述：The Italian mutation of β-amyloid 1-40 (E22K) aggregates more rapidly than the wild-type sequence 1-40. It showed increased neurotoxicity, which (according to a solid-phase NMR-study of Masuda et al.) may be due to the salt bridge formed between Lys²² and Asp²³ in the minor conformer. As the Arctic, Flemish, and Dutch mutants, the Italian mutant is degraded considerably more slowly than wild-type Aβ by neprilysin.