Cat#: 107P56
序列（三字母）：H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Gly-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
序列（单字母）：DAEFRHDSGYEVHHQKLVFFGEDVGSNKGAIIGLMVGGVV
类似名：Amyloid β-Protein (1-40) Flemish Mutation, Amyloid β-Protein (1-40) A21G, [Gly21] β-Amyloid (1-40)
分子式：C₁₉₃H₂₉₃N₅₃O₅₈S
分子量：4315.84
CAS#：154362-03-5
合成方法：固相合成
存储条件：-20 ± 5 °C，避光，干燥
应用：Alzheimer´s Disease
描述：Contrary to β-amyloid peptides mutated at position 22 (Dutch, Italian, Arctic mutants) the Flemish mutation (A21G) shows a decreased tendency to aggregate and a reduced neurotoxicity. In the studies of Betts and Tsubuki, A21G was degraded significantly more slowly by neprilysin than the wild-type Aβ 1-40 and the E22 mutants. The relative resistance to proteolytic degradation may account for the pathogenicity of the Aβ mutant.