Cat#: 107P50
序列（三字母）：(7-Diethylaminocoumarin-3-yl)carbonyl-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
序列（单字母）：(7-Diethylaminocoumarin-3-yl)carbonyl-DAEFRHDSGYEVHHQKLVFFAEDVGSAKGAIIGLMVGVV
类似名：DAC-Amyloid β-Protein (1-40)
分子式：C₂₀₈H₃₀₈N₅₄O₆₁S
分子量：4573.13
CAS#：1802087-66-6
合成方法：固相合成
存储条件：-20 ± 5 °C，避光，干燥
应用：Alzheimer´s Disease
描述：Amyloid β-protein (1-40) that is N-terminally modified with the fluorescent dye (7-diethylaminocoumarin-3-yl)carbonyl (DAC or DEAC). This derivative can be utilized to assess the binding properties of amyloid β-protein (1-40) for various membranes since it behaves very similar to the native peptide. In aqueous environments the fluorophore is almost non-fluorescent whereas binding to membranes results in an increase in fluorescence intensity (λex = 430 nm, λem = 470 nm). Increases in the GM1 ganglioside and cholesterol content in the lipid bilayers facilitated the binding of this peptide. For phosphatidylcholine and phosphatidylserine no affinity was observed.