Cat#: 107P39
序列（三字母）：H-Asp-Ala-Glu-Phe-Arg-Arg-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
序列（单字母）：DAEFRRDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
类似名：Amyloid β-Protein (1-40) English Mutation, Amyloid β-Protein (1-40) H6R
分子式：C₁₉₄H₃₀₀N₅₄O₅₈S
分子量：4348.91
CAS#：1802084-26-9
合成方法：固相合成
存储条件：-20 ± 5 °C，避光，干燥
应用：Alzheimer´s Disease
描述：The English (H6R) mutation of β-amyloid peptides accelerates fibrillation without increasing protofibril formation. Ono et al. showed that the English and Tottori mutations alter Abeta assembly at its earliest stages, monomer folding and oligomerization, and produce oligomers that are more toxic to cultured neuronal cells than are wild type oligomers. The exchange of His⁶ by Arg influences the structure of the Cu(II) complex formed by Aβ peptides.