Cat#：196P01
序列（三字母）：H-Lys-Thr-Asn-Met-Lys-His-Met-Ala-Gly-Ala-Ala-Ala-Ala-Gly-Ala-Val-Val-Gly-Gly-Leu-Gly-OH trifluoroacetate salt
序列（单字母）：KTNMKHMAGAAAAGAVVGGLG
类似名：Prion Protein Fragment (106-126), human
分子式：C₈₀H₁₃₈N₂₆O₂₄S₂
分子量：1912.27
CAS#：148439-49-0
合成方法：Synthetic
存储条件：-20 ± 5 °C
应用：Apoptosis & Necrosis
描述：An altered form of the large cellular prion protein accumulates in the CNS of patients with neurodegenerative disorders, and its protease-resistant core aggregates extracellularly into amyloid fibrils. This process is accompanied by nerve cell loss. The 21-peptide KTNMKHMAGAAAAGAVVGGLG is used as a model to investigate neurodegeneration in prion diseases. Prion Protein (106-126) forms fibrils in vitro and causes apoptotic cell death in neuron culture. Its neurotoxicity depends on the presence of microglia and is induced by microglia. It could be demonstrated that KTNMKHMAGAAAAGAVVGGLG is able to bind to DNA, a circumstance which led to the assumption that the integral protein could also bind to DNA under appropriate solution conditions.