Cat#：141P17
序列（三字母）：H-His-Ser-Asp-Ala-Ile-Phe-Thr-Gln-Gln-Tyr-Ser-Lys-Leu-Leu-Ala-Lys-Leu-Ala-Leu-Gln-Lys-Tyr-Leu-Ala-Ser-Ile-Leu-Gly-Ser-Arg-Thr-Ser-Pro-Pro-Pro-NH₂
序列（单字母）：HSDAIFTQQYSKLLAKLALQKYLASILGSRTSPPP-NH₂
分子式：C₁₇₆H₂₈₅N₄₇O₄₉
分子量：3843.49
CAS#：89468-62-2
合成方法：Synthetic
存储条件：-20 ± 5 °C
描述：Helodermin (exendin-2) was originally isolated from the venom of Gila monster (Heloderma suspectum). A high degree of sequence similarities to secretin, VIP, PHI, and GRF from mammal and bird was observed over the entire N-terminal (1-27) sequence. The isolation of helodermin was the first demonstration of the existence of a secretin/VIP-related peptide in an animal that is neither mammal nor bird. Among all known VIP-related peptides, helodermin was the most potent in stimulating cAMP production by NCI-H345 cell line.